Bodanszky M, Sharaf H, Roy J B, Said S I
Department of Medicine, State University of New York, Stony Brook 11794-8172.
Eur J Pharmacol. 1992 Jun 5;216(2):311-3. doi: 10.1016/0014-2999(92)90376-f.
The neurohypophyseal peptides arginine vasotocin, oxytocin and arginine vasopressin contracted guinea pig, rat, canine and human prostates with potencies and efficacies that were comparable to those of noradrenaline and methacholine. All three neuropeptides raised prostatic tone and elicited contractions at 10(-9) or 10(-8) M, with an order of efficacy: arginine vasotocin greater than oxytocin greater than arginine vasopressin. The findings suggest a physiological role for these peptides in prostatic smooth muscle contraction and possibly also in other aspects of male reproductive function.
神经垂体肽精氨酸血管催产素、催产素和精氨酸加压素能使豚鼠、大鼠、犬和人的前列腺收缩，其效力和效能与去甲肾上腺素和乙酰甲胆碱相当。所有这三种神经肽在10^(-9)或10^(-8) M时均可提高前列腺张力并引发收缩，效力顺序为：精氨酸血管催产素＞催产素＞精氨酸加压素。这些发现表明这些肽在前列腺平滑肌收缩中具有生理作用，并且可能在男性生殖功能的其他方面也有作用。
