维拉帕米对自发性高血压大鼠纹状体中[3H]乙酰胆碱释放的影响。

Effects of verapamil on [3H]acetylcholine release in the striatum of spontaneously hypertensive rats.

作者信息

Tsuda K, Tsuda S, Masuyama Y, Goldstein M

机构信息

Department of Medicine, Wakayama Medical College, Japan.

出版信息

Eur J Pharmacol. 1992 Jun 5;216(2):319-22. doi: 10.1016/0014-2999(92)90378-h.

DOI:10.1016/0014-2999(92)90378-h

PMID:1397017

Abstract

In the present study, we describe the effects of Ca2+ channel antagonist (verapamil) on [3H]acetylcholine (ACh) release in the central nervous system of spontaneously hypertensive rats (SHR). The electrically stimulated release of [3H]ACh from striatal slices was not different between SHR and normotensive Wistar Kyoto (WKY) rats. Verapamil inhibited electrically stimulated [3H]ACh release in a dose-related fashion. The inhibitory effect of verapamil was significantly greater in SHR than in WKY rats. These results suggest that the Ca2+ sensitivity of central cholinergic neurons might be enhanced in SHR, which could attribute, at least partially, to the pathogenesis of hypertension.

摘要

在本研究中，我们描述了钙离子通道拮抗剂（维拉帕米）对自发性高血压大鼠（SHR）中枢神经系统中[3H]乙酰胆碱（ACh）释放的影响。SHR和血压正常的Wistar Kyoto（WKY）大鼠纹状体切片中电刺激诱发的[3H]ACh释放没有差异。维拉帕米以剂量相关的方式抑制电刺激诱发的[3H]ACh释放。维拉帕米的抑制作用在SHR中比在WKY大鼠中显著更强。这些结果表明，SHR中枢胆碱能神经元的钙离子敏感性可能增强，这可能至少部分归因于高血压的发病机制。