Somani S M, Anderson J H
Drug Metab Dispos. 1977 Jan-Feb;5(1):15-8.
3-Hydroxyphenyltrimethylammonium (HPTMA) is glucuronidated in vitro by rat liver microsomes supplemented with UDP-glucuronic acid. Little reaction occurred in the postmicrosomal supernatant fraction. Triton X-100 doubled the maximal velocity for the microsomecatalyzed reaction without altering the apparent KM value for HPTMA. This is the first report of glucuronidation of a quaternary ammonium compound in vitro.
3-羟基苯基三甲基铵（HPTMA）在体外可被添加了尿苷二磷酸葡萄糖醛酸的大鼠肝微粒体进行葡萄糖醛酸化。微粒体后上清液部分几乎没有反应发生。吐温X-100使微粒体催化反应的最大速度提高了一倍，而没有改变HPTMA的表观米氏常数。这是关于季铵化合物体外葡萄糖醛酸化的首次报道。
