RINGROSE C A
Can Med Assoc J. 1963 Aug 10;89(6):246-8.
The progressive increase in world population has become a most urgent global problem in recent years. Man has, however, been interested in controlling his reproductivity at the family level for many centuries. Historical aspects of this saga are reviewed.The modern era of conception control was ushered in by Makepeace et al. in 1937 when ovulation inhibition by progesterone was demonstrated. Confirmation of this by Pincus and associates, and development of the potent oral progestational agents, the 19-norsteroids, have made efficient reliable contraception a reality.Experience with one of these agents (Ortho-Novum, 2 mg.) in 115 patients through 805 cycles is presented. Conception control was 100% effective at this dosage. Side effects were minimal. Only three of the women discontinued the tablets because of these effects. All but five in this group of 115 preferred the oral contraceptives to methods previously employed.
近年来，世界人口的不断增长已成为一个极为紧迫的全球问题。然而，几个世纪以来，人类一直致力于在家庭层面控制生育能力。本文回顾了这一漫长历程的历史背景。1937年，马克皮斯等人证实了孕酮可抑制排卵，从而开创了现代避孕时代。平卡斯及其同事对此进行了确认，并研发出了强效口服孕激素制剂——19-去甲甾体，这使得高效可靠的避孕成为现实。本文介绍了115名患者使用其中一种药物（炔诺酮片，2毫克）历经805个周期的经验。此剂量下避孕效果达100%，副作用极小。只有三名女性因这些副作用而停药。在这115名女性中，除五人外，其他人都更喜欢口服避孕药，而不是之前使用的避孕方法。
