钾与洋地黄疗效及毒性的关系。
The relation of potassium to digitalis effectiveness and toxicity.
作者信息
SAMPSON J J
出版信息
Calif Med. 1963 May;98(5):249-55.
Abstract
The concentration of potassium in the extracellular fluid, and presumably in the cell membrane and intracellular contents of the myocardial fibre, has a significant influence on the contractibility, irritability, conduction and rhythmic tendency of the heart muscle. The therapeutic and toxic dosage of digitalis is clinically affected by the variations in potassium concentrations. The range between therapeutic and toxic dosages of digitalis and sensitivity to bodily potassium depletion varies with the degree of failure of the myocardium and passive congestion of the liver.
摘要
细胞外液中的钾浓度，大概还有心肌纤维细胞膜及细胞内成分中的钾浓度，对心肌的收缩性、应激性、传导性及节律倾向有显著影响。洋地黄的治疗剂量和中毒剂量在临床上受钾浓度变化的影响。洋地黄治疗剂量与中毒剂量之间的范围以及对机体缺钾的敏感性，会因心肌衰竭程度和肝脏被动充血情况而有所不同。
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