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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Sánchez-Margalet V, Calvo J R, Lucas M, Goberna R

Department of Medical Biochemistry and Molecular Biology, Medical School, University of Sevilla, Spain.

Gen Pharmacol. 1992 Jul;23(4):637-8. doi: 10.1016/0306-3623(92)90140-f.

Pancreastatin, a 49 amino acid peptide derived from chromogranin A, has been shown to have an inhibitory effect on insulin secretion in the perfused pancreas and isolated islets. 2. We have studied the effect of pancreastatin on glucagon-stimulated insulin release and the hyperglycemic of glucagon effect in vivo. 3. When administered in the mesenteric vein, pancreastatin inhibited the increase in insulin levels induced by glucagon stimulation, thereby potentiating the hyperglycemic effect of glucagon. 4. This study describes a regulatory role of pancreastatin on glucagon-induced insulin release in vivo.

胰抑制素是一种由嗜铬粒蛋白A衍生而来的49个氨基酸的肽，已被证明对灌注胰腺和分离胰岛中的胰岛素分泌具有抑制作用。2. 我们研究了胰抑制素对胰高血糖素刺激的胰岛素释放的影响以及胰高血糖素在体内的高血糖作用。3. 当通过肠系膜静脉给药时，胰抑制素抑制了胰高血糖素刺激引起的胰岛素水平升高，从而增强了胰高血糖素的高血糖作用。4. 本研究描述了胰抑制素在体内对胰高血糖素诱导的胰岛素释放的调节作用。

Sánchez-Margalet V, Calvo J R, Lucas M, Goberna R

Department of Medical Biochemistry and Molecular Biology, Medical School, University of Sevilla, Spain.

Gen Pharmacol. 1992 Jul;23(4):637-8. doi: 10.1016/0306-3623(92)90140-f.

Pancreastatin, a 49 amino acid peptide derived from chromogranin A, has been shown to have an inhibitory effect on insulin secretion in the perfused pancreas and isolated islets. 2. We have studied the effect of pancreastatin on glucagon-stimulated insulin release and the hyperglycemic of glucagon effect in vivo. 3. When administered in the mesenteric vein, pancreastatin inhibited the increase in insulin levels induced by glucagon stimulation, thereby potentiating the hyperglycemic effect of glucagon. 4. This study describes a regulatory role of pancreastatin on glucagon-induced insulin release in vivo.

胰抑制素是一种由嗜铬粒蛋白A衍生而来的49个氨基酸的肽，已被证明对灌注胰腺和分离胰岛中的胰岛素分泌具有抑制作用。2. 我们研究了胰抑制素对胰高血糖素刺激的胰岛素释放的影响以及胰高血糖素在体内的高血糖作用。3. 当通过肠系膜静脉给药时，胰抑制素抑制了胰高血糖素刺激引起的胰岛素水平升高，从而增强了胰高血糖素的高血糖作用。4. 本研究描述了胰抑制素在体内对胰高血糖素诱导的胰岛素释放的调节作用。