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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Poli E, Monica B, Zappia L, Pozzoli C, Bertaccini G

Institute of Pharmacology, University of Parma, School of Medicine, Italy.

Gen Pharmacol. 1992 Jul;23(4):659-64. doi: 10.1016/0306-3623(92)90144-9.

The antimuscarinic activity of the selective M1-blocking drug, telenzepine, was investigated on the isolated human urinary bladder, contracted with exogenous muscarinic agonists and with field stimulation. 2. Telenzepine (3 x 10(-8)-10(-5) M) concentration-dependently shifted to the right the dose-response curves of bethanechol, acetylcholine and McN-A343, and partially depressed the electrically-evoked twitch responses. 3. pA2 values of telenzepine against bethanechol and McN-A343 were very close. 4. McN-A343 did not modify twitch responses elicited by field stimulation up to 10(-5) M. 5. The lack of muscarinic M1 receptors in human detrusor muscle is confirmed.

Poli E, Monica B, Zappia L, Pozzoli C, Bertaccini G

Institute of Pharmacology, University of Parma, School of Medicine, Italy.

Gen Pharmacol. 1992 Jul;23(4):659-64. doi: 10.1016/0306-3623(92)90144-9.

The antimuscarinic activity of the selective M1-blocking drug, telenzepine, was investigated on the isolated human urinary bladder, contracted with exogenous muscarinic agonists and with field stimulation. 2. Telenzepine (3 x 10(-8)-10(-5) M) concentration-dependently shifted to the right the dose-response curves of bethanechol, acetylcholine and McN-A343, and partially depressed the electrically-evoked twitch responses. 3. pA2 values of telenzepine against bethanechol and McN-A343 were very close. 4. McN-A343 did not modify twitch responses elicited by field stimulation up to 10(-5) M. 5. The lack of muscarinic M1 receptors in human detrusor muscle is confirmed.