Gobbetti A, Zerani M
Department of Molecular, Cellular, and Animal Biology, University of Camerino, Italy.
Gen Comp Endocrinol. 1992 Aug;87(2):163-70. doi: 10.1016/0016-6480(92)90018-f.
The present work studied the PGF2 alpha and 17 beta-estradiol plasma levels during ovulation, and the in vitro effects of mammalian gonadotropin-releasing hormone (mGnRH) on ovarian and oviductal production of prostaglandin F2 alpha (PGF2 alpha) and 17 beta-estradiol during four different stages of the annual sexual cycle in water frog, Rana esculenta. Plasma levels of PGF2 alpha increased in ovulating frogs, with respect to preovulatory and postovulatory levels, while estradiol did not change. In addition, mGnRH increased PGF2 alpha and 17 beta-estradiol in the incubation media of ovaries taken during the recovery stage. Moreover, mGnRH increased PGF2 alpha in incubation media of oviducts collected during the reproductive stage. These findings suggest that PGF2 alpha could be involved in the control of egg deposition in the female R.
本研究测定了泽蛙（Rana esculenta）在一年中的性周期四个不同阶段排卵期间血浆中前列腺素F2α（PGF2α）和17β-雌二醇的水平，以及哺乳动物促性腺激素释放激素（mGnRH）对卵巢和输卵管中PGF2α和17β-雌二醇产生的体外影响。与排卵前和排卵后水平相比，排卵时青蛙血浆中PGF2α水平升高，而雌二醇水平未发生变化。此外，mGnRH使恢复期采集的卵巢孵育培养基中PGF2α和17β-雌二醇增加。而且，mGnRH使生殖期采集的输卵管孵育培养基中PGF2α增加。这些发现表明，PGF2α可能参与雌性泽蛙产卵的调控。
