Vianelli N, Gugliotta L, Gianni L, Belmonte M M, Catani L, Tura S
Istituto di Ematologia L. e A. Seràgnoli, Università degli Studi di Bologna, Italy.
Haematologica. 1992 Jan-Feb;77(1):92-3.
We describe our experience with ascorbic acid in the treatment of chronic refractory ITP. Nine patients, 5 males and 4 females aged 27-74 years, 4 of whom were previously splenectomized, received the drug at a daily dose of 2 grams. After 2-12 months (median 4) of treatment, a partial response was observed in only one patient, while no response was registered in the other eight. Our data, analyzed together with those of the literature, allow us to conclude that ascorbic acid may not be considered a drug of interest in the treatment of chronic refractory ITP.
我们描述了使用抗坏血酸治疗慢性难治性免疫性血小板减少症（ITP）的经验。9名患者，5名男性和4名女性，年龄在27至74岁之间，其中4人曾接受过脾切除术，接受该药物治疗，每日剂量为2克。经过2至12个月（中位数为4个月）的治疗，仅1例患者出现部分缓解，而其他8例无反应。我们的数据与文献数据综合分析后，得出结论：抗坏血酸可能不被视为治疗慢性难治性ITP的有效药物。
