临床医学中的肌酐清除率。
Creatinine clearance in clinical medicine.
作者信息
TJAN H L, TOBIAS G J, LEVIN R, HOPPER J
出版信息
Calif Med. 1963 Mar;98(3):121-8.
Clearance of endogenous creatinine offers a reliable clinical means of determining quantitative renal damage. The rate of clearance (Ccr) is obtained by relating the amount of creatinine filtered by the glomerulus per unit of time to the concentration of creatinine in the serum. The technic is simple and practical for routine use. Since 1948, the creatinine clearance determination has been used extensively at the University of California Medical Center for the evaluation of renal function. The present report reviews our selected experience with this procedure during the past 14 years. Clinical examples are used to show that the Ccr is a more accurate index of glomerular filtration than the concentration of any of the nonprotein nitrogen components of the blood.
内源性肌酐清除率为定量评估肾脏损害提供了一种可靠的临床方法。清除率（Ccr）通过将单位时间内肾小球滤过的肌酐量与血清中肌酐浓度相关联来获得。该技术简单实用，适用于常规应用。自1948年以来，肌酐清除率测定在加利福尼亚大学医学中心被广泛用于评估肾功能。本报告回顾了我们在过去14年中使用该方法的特定经验。通过临床实例表明，Ccr作为肾小球滤过功能的指标比血液中任何一种非蛋白氮成分的浓度更为准确。
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