[Study on variation of plasma gamma-aminobutyric acid concentration in rat model of hepatic encephalopathy due to fulminant hepatic failure].

The plasma gamma-aminobutyric acid (GABA) concentration was measured by a radio-receptor assay in rat model of hepatic encephalopathy due to fulminant hepatic failure (FHF) induced by intraperitoneal injection of D-galactosamine (GalN). The results showed that, in FHF group, the plasma GABA increased parallelly with the degree of hepatic encephalopathy after GalN i.p. (r = 0.944, P less than 0.05). In about 48 h, mean plasma GABA concentration was elevated nearly 8-fold. These findings suggest that, in liver failure, elevated plasma GABA concentration may play a role in the pathogenesis of hepatic encephalopathy.