苯妥英治疗隐性营养不良性大疱性表皮松解症。

Recessive dystrophic epidermolysis bullosa treated with phenytoin.

作者信息

Abahussein A A, al-Zayir A A, Mostafa W Z, Okoro A N

机构信息

Department of Dermatology, College of Medicine and Medical Sciences, King Faisal University, Dammam, Saudi Arabia.

出版信息

Int J Dermatol. 1992 Oct;31(10):730-2. doi: 10.1111/j.1365-4362.1992.tb01385.x.

DOI:10.1111/j.1365-4362.1992.tb01385.x

PMID:1399206

Abstract

Three patients with severe recessive dystrophic epidermolysis bullosa were treated with oral phenytoin and palliative and supportive measures for variable periods. Their progress was compared with that of three milder cases managed only with palliative and supportive measures. The phenytoin-treated group showed marked decrease in blister count, increase in trauma tolerance, a rise in hemoglobin level, and considerable weight gain. The results support earlier reports that collagenase inhibitors are useful in controlling blister formation in recessive dystrophic epidermolysis bullosa.

摘要

三名患有严重隐性营养不良性大疱性表皮松解症的患者接受了口服苯妥英钠治疗，并在不同时期采取了姑息和支持措施。将他们的病情进展与另外三名仅采取姑息和支持措施的病情较轻患者进行了比较。接受苯妥英钠治疗的组水疱数量明显减少，创伤耐受性增强，血红蛋白水平升高，体重显著增加。这些结果支持了早期的报告，即胶原酶抑制剂有助于控制隐性营养不良性大疱性表皮松解症中的水疱形成。