Bassi P, Brunati L, Rapuzzi B, Alberti E, Mangoni A
Department of Neurology, University of Milan, Luigi Sacco Hospital, Italy.
Headache. 1992 Sep;32(8):390-2. doi: 10.1111/j.1526-4610.1992.hed3208390.x.
In a period of one year (1990) we selected 40 patients suffering from migraine. For an open randomized study there were 2 groups of patients: the first were treated with 10mg of flunarizine per day and the second with 3 mg per day. The patients were treated for 4 months consecutively. There were 11 drop outs (27.5%): nine for poor compliance and 2 due to side effects. The efficacy of flunarizine in the prophylaxis of migraine was essentially identical in the two dosage groups while the incidence of side effects was considerably reduced in the patients treated with the lower dose.
在一年期间（1990年），我们挑选了40名偏头痛患者。为进行一项开放性随机研究，将患者分为两组：第一组患者每天服用10毫克氟桂利嗪，第二组患者每天服用3毫克。患者连续接受4个月的治疗。共有11名患者退出（27.5%）：9名是因为依从性差，2名是由于副作用。两个剂量组中氟桂利嗪预防偏头痛的疗效基本相同，而低剂量治疗的患者副作用发生率显著降低。
