Spitz M R, Sider J G, Schantz S P, Newell G R
Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Head Neck. 1992 Sep-Oct;14(5):347-51. doi: 10.1002/hed.2880140502.
Cancers of the cervix and buccal cavity share histologic, epidemiologic, and exposure characteristics. In particular, cigarette smoking and human papillomavirus (HPV) have been cited as etiologic cofactors of both malignancies. Using incidence data from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute for the years 1973 through 1984, we evaluated the incidence of second cancers of the buccal cavity following an initial cervical cancer. Standardized incidence ratios (SIR) were uniformly elevated for both white (SIR = 2.0), and black (SIR = 3.5) women. There were also elevated risks for the development of cervical cancer following an initial buccal cavity cancer (SIRs = 3.3 and 2.5, respectively). A similar pattern was evident for laryngeal cancer among white women. HPV transmission could account in part for the paired occurrence of these two anatomically distinct cancer sites. Cigarette smoking could act as a synergistic cofactor in the malignant transformation of viral genome-harboring tissue.
宫颈癌和口腔癌具有共同的组织学、流行病学及暴露特征。尤其是，吸烟和人乳头瘤病毒（HPV）被认为是这两种恶性肿瘤的病因协同因素。利用美国国立癌症研究所监测、流行病学和最终结果（SEER）项目1973年至1984年的发病率数据，我们评估了初诊宫颈癌后口腔第二原发癌的发病率。白人（标准化发病比[SIR]=2.0）和黑人（SIR=3.5）女性的标准化发病比均一致升高。初诊口腔癌后发生宫颈癌的风险也升高（SIR分别为3.3和2.5）。白人女性喉癌也呈现类似模式。HPV传播可能部分解释了这两个解剖学上不同的癌症部位成对出现的现象。吸烟可能在携带病毒基因组的组织的恶性转化中起到协同辅助因素的作用。
