Tariq M A, Preiss I L
Department of Chemistry, Rensselaer Polytechnic Institute, Troy, NY 12180.
Int J Rad Appl Instrum B. 1992 Jul;19(5):555-61. doi: 10.1016/0883-2897(92)90151-n.
The distribution of selenate and selenite selenium in C57L/J mice during the progression of BW7756 murine hepatoma was investigated using intra-ocular injection with the oxyanions labeled with 75Se radioisotope. Comparison is made with the normal distribution of selenium studied by the RIXRF method. The trace elemental profiles, TEP, for the two oxidation states are compared in healthy and disease states. It has been found that the presence of tumor significantly changes the level of tracer in various uninvolved organs. These changes are prominent in the early growth phase of the tumor. The two oxidation states show differences in the TEP for kidney, spleen, stomach and testes.
利用眼内注射用75Se放射性同位素标记的含氧阴离子，研究了BW7756小鼠肝癌进展过程中硒酸盐和亚硒酸盐硒在C57L/J小鼠体内的分布情况。并与通过RIXRF方法研究的硒的正常分布进行了比较。比较了两种氧化态在健康和疾病状态下的微量元素谱（TEP）。结果发现，肿瘤的存在显著改变了各种未受累器官中示踪剂的水平。这些变化在肿瘤的早期生长阶段尤为明显。两种氧化态在肾脏、脾脏、胃和睾丸的TEP上存在差异。
