Mansfield L S, Schad G A
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.
J Am Vet Med Assoc. 1992 Sep 1;201(5):726-30.
Treatment of Strongyloides stercoralis infection was investigated in 2 dogs with naturally acquired, chronic-active infections, and in 3 dogs with corticosteroid-enhanced, experimentally induced hyperinfections. A single oral dose of ivermectin was given to naturally infected (200 micrograms/kg of body weight) and experimentally infected (800 micrograms/kg) dogs. Five dogs with experimental hyperinfections served as controls. Dogs with naturally acquired infections ceased to shed first-stage larvae in the feces 1 week after treatment, but 1 dog had recrudescence and required a second dose. Ivermectin was 100% effective in removing adult S stercoralis from the intestinal tract of the experimentally infected dogs, but it was not effective in removing third-stage larvae from parenteral sites. Ivermectin-treated dogs had few intestinal parasites of any stage, whereas at necropsy, 4 of 5 experimentally infected dogs not treated had massive infections (greater than 100,000 adults, greater than 92,000 larvae) in the intestinal tract, and 3 of 5 had larvae (greater than 2,500) in parenteral sites.
在2只自然感染慢性活动性粪类圆线虫的犬以及3只通过皮质类固醇增强实验诱导的超感染犬中，对粪类圆线虫感染的治疗进行了研究。给自然感染犬（200微克/千克体重）和实验感染犬（800微克/千克）口服单剂量伊维菌素。5只实验性超感染犬作为对照。自然感染的犬在治疗1周后粪便中不再排出第一期幼虫，但有1只犬复发，需要再次给药。伊维菌素在清除实验感染犬肠道内的成虫粪类圆线虫方面100%有效，但在清除非肠道部位的第三期幼虫方面无效。经伊维菌素治疗的犬肠道内任何阶段的寄生虫都很少，而在尸检时，5只未治疗的实验感染犬中有4只肠道内有大量感染（成虫超过100,000条，幼虫超过92,000条），5只中有3只在非肠道部位有幼虫（超过2,500条）。
