[可卡因治疗对大鼠脑内多巴胺和5-羟色胺再生水平以及乙酰胆碱水平的影响]
[The effect of cocaine treatment on the level of dopamine and serotonin regeneration and on the level of acetylcholine in rat brain].
作者信息
Lallemant A M, Bralet J
出版信息
C R Seances Soc Biol Fil. 1976;170(5):1056-63.
PMID:139979
Abstract
Cocaine treatment (10 or 50 mg/kg, i.m.): 1) did not change significantly the amount of 3H dopamine synthesized from 3H tyrosine in the striatum but reduced the specific activity of 3H tyrosine; 2) delayed the release of cerebral dopamine after inhibition of its biosynthesis by alpha-methylparatyrosine; 3) reduced the amount of 5-hydroxyindolacetic acid accumulated after Probenecid, which reflects an inhibitory effect on serotonin release; 4) did not change significantly the acetylcholine level of the brain.
摘要
可卡因治疗（10或50毫克/千克，肌肉注射）：1）纹状体中由3H酪氨酸合成的3H多巴胺量无显著变化，但3H酪氨酸的比活性降低；2）在α-甲基对酪氨酸抑制其生物合成后，延迟了脑多巴胺的释放；3）降低了丙磺舒后积累的5-羟吲哚乙酸量，这反映了对血清素释放的抑制作用；4）脑中乙酰胆碱水平无显著变化。
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