WATKINS W M
Immunology. 1962 Mar;5(2):245-66.
The action of partially purified enzyme preparations from on the serological properties of the water-soluble A, B, H and Le human blood-group substances has been examined. Further evidence has been obtained for the presence in A and B substances of structures closely similar to, or identical with, the specific determinant groupings in H substance. In addition, it has been shown that enzymic destruction of H serological properties results in certain instances in a considerable increase in the reactivity of the H substance with Lewis anti-Le sera. The capacity to develop Le specificity appears to be related to the Lewis blood-group phenotype of the individual from whom the H substance is derived. The significance of these results is discussed in relation to schemes which were put forward earlier for the biosynthesis of the blood-group mucopolysaccharides.
已对从[来源]获得的部分纯化酶制剂作用于水溶性A、B、H及Le人类血型物质血清学特性的情况进行了研究。已获得进一步证据，证明A和B物质中存在与H物质中的特异性决定簇分组极为相似或相同的结构。此外，还表明在某些情况下，H血清学特性的酶促破坏会导致H物质与抗Le Lewis血清的反应性显著增加。产生Le特异性的能力似乎与H物质所源自个体的Lewis血型表型有关。结合早期提出的血型粘多糖生物合成方案，对这些结果的意义进行了讨论。
