4-氨基蝶酰谷氨酸（氨甲蝶呤）对大鼠小肠黏膜影响的光镜和电镜研究。
Light- and electron-microscope studies of the effects of 4-aminopteroylglutamic acid (aminopterin) on the mucous membrane of the small intestine of the rat.
作者信息
WILLIAMS A W
出版信息
Gut. 1961 Dec;2(4):346-51. doi: 10.1136/gut.2.4.346.
Abstract
Aminopterin, a cytotoxic agent, causes mitotic arrest by interfering with the catabolism of ribonucleoprotein. The effects on the small intestine are demonstrated. The resulting atrophy, with changes in the microvilli, is associated with severely impaired fat absorption.
摘要
氨基蝶呤是一种细胞毒性药物，通过干扰核糖核蛋白的分解代谢导致有丝分裂停滞。已证实其对小肠的影响。由此产生的萎缩，伴有微绒毛的变化，与严重受损的脂肪吸收有关。
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