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4-氨基蝶酰谷氨酸（氨甲蝶呤）对大鼠小肠黏膜影响的光镜和电镜研究。

Light- and electron-microscope studies of the effects of 4-aminopteroylglutamic acid (aminopterin) on the mucous membrane of the small intestine of the rat.

作者信息

WILLIAMS A W

出版信息

Gut. 1961 Dec;2(4):346-51. doi: 10.1136/gut.2.4.346.

DOI:10.1136/gut.2.4.346
PMID:14007115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1413356/
Abstract

Aminopterin, a cytotoxic agent, causes mitotic arrest by interfering with the catabolism of ribonucleoprotein. The effects on the small intestine are demonstrated. The resulting atrophy, with changes in the microvilli, is associated with severely impaired fat absorption.

摘要

氨基蝶呤是一种细胞毒性药物，通过干扰核糖核蛋白的分解代谢导致有丝分裂停滞。已证实其对小肠的影响。由此产生的萎缩，伴有微绒毛的变化，与严重受损的脂肪吸收有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/354e6e6465b2/gut00679-0080-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/9d2c8fcf60bc/gut00679-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/592097f20ad8/gut00679-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/720b34348502/gut00679-0078-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/46cf0330fede/gut00679-0078-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/7c1d5865d41d/gut00679-0078-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/aad42981e231/gut00679-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/104ed5daa02e/gut00679-0079-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/b7ff8c64c219/gut00679-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/02369043a864/gut00679-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/354e6e6465b2/gut00679-0080-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/9d2c8fcf60bc/gut00679-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/592097f20ad8/gut00679-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/720b34348502/gut00679-0078-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/46cf0330fede/gut00679-0078-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/7c1d5865d41d/gut00679-0078-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/aad42981e231/gut00679-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/104ed5daa02e/gut00679-0079-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/b7ff8c64c219/gut00679-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/02369043a864/gut00679-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aca/1413356/354e6e6465b2/gut00679-0080-c.jpg

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1
Light- and electron-microscope studies of the effects of 4-aminopteroylglutamic acid (aminopterin) on the mucous membrane of the small intestine of the rat.4-氨基蝶酰谷氨酸（氨甲蝶呤）对大鼠小肠黏膜影响的光镜和电镜研究。
Gut. 1961 Dec;2(4):346-51. doi: 10.1136/gut.2.4.346.
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引用本文的文献

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Electron microscopic changes associated with water absorption in the jejunum.空肠中与水分吸收相关的电子显微镜下的变化。
Gut. 1963 Mar;4(1):1-7. doi: 10.1136/gut.4.1.1.
3
Experimental intestinal malabsorption states and their relation to clinical syndromes.实验性肠道吸收不良状态及其与临床综合征的关系。

本文引用的文献

1
The effects of a folic acid antagonist (aminopterin) on albino rats; a study in the pathogenesis of sprue.一种叶酸拮抗剂（氨蝶呤）对白化大鼠的影响；热带口炎性腹泻发病机制的研究
Br J Exp Pathol. 1951 Oct;32(5):458-61.
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Histopathologic studies in steatorrhea.脂肪痢的组织病理学研究。
Gastroenterology. 1960 Mar;38:419-40.
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Electron microscopy studies of butter and corn oil in jejunal mucosa.空肠黏膜中黄油和玉米油的电子显微镜研究。
Klin Wochenschr. 1972 Feb 15;50(4):173-85. doi: 10.1007/BF01487140.
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[Intestinal disaccharidases in rats treated with 5-fluoro-uracil (author's transl)].5-氟尿嘧啶处理的大鼠肠道双糖酶（作者译）
Klin Wochenschr. 1974 Oct 1;52(19):930-8. doi: 10.1007/BF01468940.
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[Cytostatica and small intestine (author's transl)].[细胞抑制剂与小肠（作者译）]
Klin Wochenschr. 1978 Jun 15;56(12):579-92. doi: 10.1007/BF01477006.
Arch Pathol. 1960 Feb;69:121-9.
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Jejunal biopsy in adult coeliac disease and allied disorders.成人乳糜泻及相关疾病的空肠活检
Lancet. 1960 Apr 30;1(7131):933-9. doi: 10.1016/s0140-6736(60)90832-1.
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Jejunal biopsy in malabsorptive disorders of the adult.成人吸收不良性疾病的空肠活检
Br Med J. 1961 Feb 4;1(5222):319-23. doi: 10.1136/bmj.1.5222.319.
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Disorders related to disturbed absorption of the small bowel.与小肠吸收紊乱相关的疾病。
Adv Intern Med. 1960;10:137-78.
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Small intestinal biopsy: diagnostic and research value.小肠活检：诊断及研究价值
Proc R Soc Med. 1959 Jan;52(1):10-4. doi: 10.1177/003591575905200103.
8
Jejunal biopsies in sprue.口炎性腹泻的空肠活检
Ann Intern Med. 1958 Jan;48(1):8-29. doi: 10.7326/0003-4819-48-1-8.
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Effects of aminopterin administration on the respiration and morphology of the gastrointestinal mucosa of rats.
J Lab Clin Med. 1954 Apr;43(4):583-94.