Schmidt-Elmendorff H, Steyer M
Geburtshilfe Frauenheilkd. 1977 Apr;37(4):297-303.
The paper refers to 167 patients who were treated with 2 mg Cyproteronacetate and 50 mug Ethinyloestradiol because of acne, seborrhoea, hirsutism and androgenetic alopecia. The application was daily from the 5th to the 25th day of cycle over a period of 12 months. The success of treatment depended on the severity of virilisation: in cases of light acne only 77% of the patients showed improvement, while in cases of severe acne 91,4% showed improvement or healing of acne. The corresponding figures for seborrhoea were 55,7% and 89,4% respectively, and for hirsutism 37,4% and 60,9% respectively. Furthermore the success of treatment of the different virilising symptoms depended on the duration of therapy: while acne was already cured significantly after 6 months of treatment, seborrhoea and hirsutism show continuous improvement up to the 10th month thetherapy. Concerning side effects during therapy spottings and brake through bleedings were registered in 17,1 and 6% of cycles respectively. 16,2% of the patients noted breast tensions. Finally 68,7% of the patients suffered from nervousness, a very subjective symptom, which might be explained by the psychic lability accompanying virilising symptoms. The drop out rate was 7,8%, being not higher than with other oral contraceptives.
该论文涉及167例因痤疮、脂溢性皮炎、多毛症和雄激素性脱发而接受2毫克醋酸环丙孕酮和50微克乙炔雌二醇治疗的患者。给药方式为在月经周期的第5天至第25天每日用药，持续12个月。治疗的成功率取决于男性化的严重程度：在轻度痤疮病例中，只有77%的患者病情有所改善，而在重度痤疮病例中，91.4%的患者痤疮有所改善或痊愈。脂溢性皮炎的相应数字分别为55.7%和89.4%，多毛症的相应数字分别为37.4%和60.9%。此外，不同男性化症状的治疗成功率还取决于治疗持续时间：治疗6个月后痤疮就已显著治愈，而脂溢性皮炎和多毛症在治疗至第10个月时仍持续改善。关于治疗期间的副作用，分别有17.1%和6%的周期出现点滴出血和突破性出血。16.2%的患者出现乳房胀痛。最后，68.7%的患者出现紧张情绪，这是一种非常主观的症状，可能是由男性化症状伴随的精神易激惹所解释。脱落率为7.8%，不高于其他口服避孕药。
