Padhye A A, Kaufman L, Durry E, Banerjee C K, Jindal S K, Talwar P, Chakrabarti A
Mycotic Diseases Branch, Centers for Disease Control, Atlanta, Georgia 30333.
J Clin Microbiol. 1992 Sep;30(9):2492-4. doi: 10.1128/jcm.30.9.2492-2494.1992.
The first case of fatal pulmonary sporotrichosis caused by Sporothrix schenckii var. luriei in a patient from the northwestern region of India is described. In the absence of cultures, the diagnosis was suspected by notation, in lung tissue, of large, thick-walled, hyaline fungal cells that divided internally by septation or a budding process. The thick-walled, internally septated cells often became muriform. The presence of an "eyeglass" configuration of incompletely separated cells characteristic of S. schenckii var. luriei in large numbers aided the diagnosis. The identity of the etiologic agent was confirmed by application of a fluorescent-antibody reagent specific for S. schenckii.
本文描述了印度西北部一名患者因申克孢子丝菌卢里变种（Sporothrix schenckii var. luriei）导致的首例致命性肺孢子丝菌病。在未进行培养的情况下，通过在肺组织中发现大型、厚壁、透明的真菌细胞，这些细胞通过隔膜或出芽过程在内部进行分裂，从而怀疑该诊断。厚壁、内部有隔膜的细胞常变成砖格状。大量存在申克孢子丝菌卢里变种特有的不完全分离细胞的“眼镜”构型有助于诊断。通过应用针对申克孢子丝菌的荧光抗体试剂，确认了病原体的身份。
