卢里孢子丝菌在播散性感染的小鼠模型中的毒力。
Virulence of Sporothrix luriei in a murine model of disseminated infection.
机构信息
Unitat d'Anatomia Patològica, Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
出版信息
Mycopathologia. 2012 Apr;173(4):245-9. doi: 10.1007/s11046-011-9506-7. Epub 2011 Dec 3.
Sporothrix luriei is a rare fungus causing sporotrichosis in humans. The virulence of this fungus was evaluated in a murine model of disseminated infection. Mice were challenged intravenously with two different inocula (2 × 10(5) and 2 × 10(7) CFU/animals) but only the highest one was able to kill the animals. Infected mice died between days 12 and 16, liver and spleen being the most affected organs. In the infected tissues, a massive infiltration of fungal cells and phagocytes were observed, but not the typical "eyeglass" cells described in infected human tissue.
卢里球孢子菌是一种罕见的真菌，可引起人类孢子丝菌病。该真菌的毒力在播散性感染的小鼠模型中进行了评估。小鼠通过静脉内接受两种不同的接种物（2×10（5）和 2×10（7）CFU/动物）进行挑战，但只有最高接种物能够杀死动物。感染的小鼠在第 12 天至第 16 天之间死亡，肝脏和脾脏是受影响最严重的器官。在感染的组织中，观察到大量真菌细胞和吞噬细胞的浸润，但没有在感染的人类组织中描述的典型“眼镜”细胞。
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