血糖与免疫反应。
Glycemia and immune responses.
作者信息
ADAMKIEWICZ V W
出版信息
Can Med Assoc J. 1963 Apr 13;88(15):806-11.
Abstract
The intensity of experimental and clinical immune responses was correlated with the degree of glycemia of the reacting subject. Hyperglycemias resulting from overdosage with sugars, cortisol, adrenaline, or from diabetes inhibit the anaphylactoid reactions; anaphylaxis, and the tuberculin reaction; but potentiate infections. Hypoglycemias resulting from fasting, insulin and adrenalectomy potentiate the anaphylactoid reactions, anaphylaxis, and the tuberculin reaction; but inhibit infections. The hypothesis is proposed that hyperglycemia inhibits certain antigen-antibody combinations; this results in an inhibition of hypersensitivity, but an aggravation of infection.
摘要
实验性和临床免疫反应的强度与反应个体的血糖程度相关。因糖类、皮质醇、肾上腺素过量或糖尿病导致的高血糖会抑制类过敏反应、过敏反应和结核菌素反应，但会加重感染。因禁食、胰岛素和肾上腺切除术导致的低血糖会增强类过敏反应、过敏反应和结核菌素反应，但会抑制感染。有人提出这样的假说：高血糖会抑制某些抗原 - 抗体结合；这会导致超敏反应受到抑制，但感染会加重。
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6
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7
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本文引用的文献
1
Insulin and hypersensitivity.
Nature. 1959 Dec 26;184(Suppl 26):2020. doi: 10.1038/1842020a0.
2
Subcutaneous growth of normal and malignant human tissues in heterologous hosts.
Trans N Y Acad Sci. 1955 Jun;17(8):589-93. doi: 10.1111/j.2164-0947.1955.tb03494.x.
3
Fundamental concepts underlying the metabolic periodicity in diabetes.
Ann N Y Acad Sci. 1962 Oct 30;98:984-94. doi: 10.1111/j.1749-6632.1962.tb30613.x.
4
Studies on the prevention of sensitization by Bordetella pertussis in alloxan diabetic mice.
Can J Biochem Physiol. 1962 Sep;40:1179-83.
5
Inhibition of anaphylactoid edema in the rat by 2-deoxyglucose.
Am J Physiol. 1959 Nov;197:1056-8. doi: 10.1152/ajplegacy.1959.197.5.1056.
6
Hypoglycemic drugs and the dextran 'anaphylactoid' inflammation.
Can J Biochem Physiol. 1960 Aug;38:823-7.
7
Alloxan diabetes and dextran anaphylactoid inflammation.
Am J Physiol. 1959 Aug;197:377-9. doi: 10.1152/ajplegacy.1959.197.2.377.
8
Alloxan and hypersensitivity.
Nature. 1961 May 27;190:822. doi: 10.1038/190822a0.
9
Sensitization by insulin to dextran anaphylactoid inflammation in spinal rats.
Am J Physiol. 1958 Dec;195(3):635-8. doi: 10.1152/ajplegacy.1958.195.3.635.
10
Inhibition of histamine release in experimental diabetes.
Am J Physiol. 1957 Oct;191(1):25-8. doi: 10.1152/ajplegacy.1957.191.1.25.
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