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氨基四氢萘类作为选择性β-肾上腺素能激动剂。

Aminotetralins as selective beta-adrenergic agonists.

作者信息

Ilhan M, Kitzen J M, Cannon J G, Long J P

出版信息

Eur J Pharmacol. 1977 Feb 7;41(3):301-6. doi: 10.1016/0014-2999(77)90323-5.

DOI:10.1016/0014-2999(77)90323-5
PMID:14012
Abstract

Aminotetralin derivatives M-8 and JOD-176, were studied in relation to isoproterenol for beta-adrenergic activity. M-8 and JOD-176 were found to be very weak in activating cardiac beta-receptors. These compounds were also found to be considerably more active in uterine and bronchial smooth muscle. Because these compounds were also shown to be very inactive in vascular smooth muscle, the possibility that beta-receptors in different smooth muscle types may also differ was suggested.

摘要

对氨基四氢萘衍生物M - 8和JOD - 176进行了与异丙肾上腺素相关的β - 肾上腺素能活性研究。发现M - 8和JOD - 176在激活心脏β受体方面作用非常微弱。还发现这些化合物在子宫和支气管平滑肌中活性明显更高。由于这些化合物在血管平滑肌中也显示出非常低的活性，因此有人提出不同类型平滑肌中的β受体可能也存在差异。

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