Böhler-Sommeregger K, Schuller-Petrovic S, Knobler R, Neumann P R
Department of Dermatology II, University of Vienna, Austria.
J Am Acad Dermatol. 1992 Oct;27(4):523-6. doi: 10.1016/0190-9622(92)70216-3.
Twenty patients treated for lentigo maligna of the face with cryosurgery developed benign lentiginous hyperpigmentation mimicking a recurrence.
When cryosurgery is used in the treatment of lentigo maligna, it is important to know whether repigmentation of the scar represents true recurrence or a benign process.
Twenty patients were treated with cryosurgery for lentigo maligna of the face. Within a follow-up period of 7 to 80 months, frequent clinical observations were made.
Lentiginous hyperpigmentation developed within the treatment area in eight patients. Histologic investigation revealed recurrence of lentigo maligna in three and benign hyperpigmentation in five.
Genetic factors and UV exposure after cryosurgery may favor the development of benign lentiginous hyperpigmentation. Because recurrence of lentigo maligna must be considered, histologic evaluation of repigmentation is mandatory.
20例面部恶性雀斑样痣接受冷冻治疗的患者出现了类似复发的良性雀斑样色素沉着。
当使用冷冻治疗恶性雀斑样痣时，了解瘢痕的色素重新沉着是代表真正复发还是良性过程很重要。
20例面部恶性雀斑样痣患者接受了冷冻治疗。在7至80个月的随访期内，进行了频繁的临床观察。
8例患者在治疗区域出现了雀斑样色素沉着。组织学检查显示3例为恶性雀斑样痣复发，5例为良性色素沉着。
冷冻治疗后的遗传因素和紫外线暴露可能有利于良性雀斑样色素沉着的发展。由于必须考虑恶性雀斑样痣的复发，因此对色素重新沉着进行组织学评估是必要的。
