Ross J S, McKee P H, Smith N P, Shimizu H, Griffiths W A, Bhogal B S, Black M M
St John's Dermatology Centre, St Thomas's Hospital, London, England.
J Cutan Pathol. 1992 Jun;19(3):212-6. doi: 10.1111/j.1600-0560.1992.tb01661.x.
We report three patients with pemphigoid nodularis. Patients were females aged 76, 71 and 50 years, and all had features of bullous pemphigoid together with prurigo-like lesions at some stage of their illness. In two cases, nodular lesions preceded the onset of blistering by some months. Blisters arose on normal skin and in one patients also at sites of prurigo lesions. Routine histology of bullous lesions revealed the presence of subepidermal blisters. Electron microscopy performed in two cases confirmed the level of split to be through the lamina lucida. Direct immunofluorescence in all cases was positive, with linear basement membrane zone deposition of IgG and C3. Circulating IgG anti-basement membrane antibody was also detected in all patients, and in two, immunoblotting revealed a single antigen of 220 kD.
我们报告了3例结节性类天疱疮患者。患者均为女性，年龄分别为76岁、71岁和50岁，在病程的某些阶段均有大疱性类天疱疮的特征以及类痒疹样皮损。在2例患者中，结节性皮损在水疱出现前数月就已出现。水疱出现在正常皮肤上，其中1例患者的水疱也出现在痒疹皮损部位。大疱性皮损的常规组织学检查显示有表皮下水疱。对2例患者进行的电子显微镜检查证实分裂平面位于透明层。所有病例的直接免疫荧光检查均为阳性，IgG和C3呈线性沉积于基底膜带。所有患者均检测到循环IgG抗基底膜抗体，其中2例患者经免疫印迹法检测显示有一条220 kD的单一抗原条带。
