Dustoor M, Croft W, Fulton A, Blazkovec A
Infect Immun. 1977 Mar;15(3):916-24. doi: 10.1128/iai.15.3.916-924.1977.
Randomly bred guinea pigs were infected with Listeria monocytogenes using the intracardial, intravenous and intraperitoneal routes of infection. Doses of Listeria ranged from 5 to 1,000 x the 50% lethal dose based on the 50% lethal dose for intracardially injected Listeria. A complete necropsy was performed on all animals that died after infection. Gross and microscopic examination of tissues revealed major pathological features which include myocarditis, edema and congestion with interstitial pneumonitis present in the lungs, and fatty hepatic changes with focal necrosis. For all or a majority of the animals, large numbers of Listeria were likewise recovered from these organs and from lymph nodes, spleen, kidneys, and adrenal gland tissue. Of the three routes of infection used, guinea pigs were most susceptible to Listeria injected via the intracardial route. The relatively high lethal dose of listeric for the quinea pig, however, suggests that the organism is a low-grade pathogen for this species.
随机繁殖的豚鼠通过心内、静脉和腹腔途径感染单核细胞增生李斯特菌。根据心内注射李斯特菌的半数致死剂量，李斯特菌的剂量范围为5至1000倍半数致死剂量。对感染后死亡的所有动物进行了完整的尸检。组织的大体和显微镜检查揭示了主要病理特征，包括心肌炎、水肿和充血，肺部出现间质性肺炎，以及脂肪性肝脏改变伴局灶性坏死。对于所有或大多数动物，同样从这些器官以及淋巴结、脾脏、肾脏和肾上腺组织中分离出大量李斯特菌。在所使用的三种感染途径中，豚鼠对通过心内途径注射的李斯特菌最为敏感。然而，李斯特菌对豚鼠相对较高的致死剂量表明该病原体对该物种而言是低毒力的。
