Marco A J, Prats N, Ramos J A, Briones V, Blanco M, Dominguez L, Domingo M
Departamento de Patología y Producciones Animales, Facultad de Veterinaria, Universidad Autónoma de Barcelona, Bellaterra.
J Comp Pathol. 1992 Jul;107(1):1-9. doi: 10.1016/0021-9975(92)90090-h.
The course of murine infection after intragastric inoculation of L. monocytogenes was investigated by immunocytochemical, histopathological and microbiological techniques. L. monocytogenes antigen was observed in epithelial cells of intestinal mucosa overlying Peyer's patches, but not in mucosa devoid of them. This suggests that penetration of L. monocytogenes into the host organism may take place through epithelium overlying Peyer's patches. The efficiency of bacterial penetration appeared to be low, as shown by the small amounts of L. monocytogenes antigen detected and the low counts of bacteria in organs. Gross or histopathological lesions in the intestinal tract were not observed. The presence of L. monocytogenes in spleen, liver and in maxillary and mesenteric lymph nodes, confirmed that the systemic course of infection by this route of inoculation is similar to that of the parenteral routes. The results emphasize the subclinical character of murine listeriosis by the oral route.
通过免疫细胞化学、组织病理学和微生物学技术研究了经胃内接种单核细胞增生李斯特菌后小鼠的感染过程。在派尔集合淋巴结上方的肠黏膜上皮细胞中观察到了单核细胞增生李斯特菌抗原，但在没有派尔集合淋巴结的黏膜中未观察到。这表明单核细胞增生李斯特菌进入宿主机体可能是通过派尔集合淋巴结上方的上皮。如检测到的少量单核细胞增生李斯特菌抗原以及器官中细菌数量较低所示，细菌穿透效率似乎较低。未观察到肠道的肉眼或组织病理学病变。脾脏、肝脏以及上颌和肠系膜淋巴结中存在单核细胞增生李斯特菌，证实了通过这种接种途径感染的全身过程与肠外途径相似。结果强调了经口途径小鼠李斯特菌病的亚临床特征。
