Kanzaki T, Eto H, Miyazawa S
Department of Dermatology, Nagoya City University Medical School, Japan.
J Dermatol. 1992 Aug;19(8):487-92. doi: 10.1111/j.1346-8138.1992.tb03267.x.
A 35-year-old woman exhibited bluish-brown discoloration of her buccal mucosa suggesting malignant melanoma. Histopathological examination revealed that the pigment was not melanin but caused by metal deposits. Electron microscopically, metallic particles were located on the lamina densa of basal laminae at mucosal epithelium, nerve fibers, and blood vessels and on the microfilaments of elastic fibers as well as in macrophages and fibroblasts. Electron microscopic point X-ray microanalysis revealed that these metallic particles were composed of Ag, Se, Fe, Co, Cu, and S. Analysis suggests that these metals were derived from dental amalgam and that the discoloration was caused by amalgam tattoo.
一名35岁女性的颊黏膜出现蓝褐色变色，提示为恶性黑色素瘤。组织病理学检查显示，色素并非黑色素，而是由金属沉积所致。电子显微镜检查发现，金属颗粒位于黏膜上皮、神经纤维和血管的基底膜致密层上，以及弹性纤维的微丝上，同时也存在于巨噬细胞和成纤维细胞中。电子显微镜点X射线微分析显示，这些金属颗粒由银、硒、铁、钴、铜和硫组成。分析表明，这些金属源自牙科汞合金，变色是由汞合金纹身引起的。
