叶酸从大鼠小肠的吸收。
Absorption of folic acid from the small intestine of the rat.
作者信息
BURGEN A S, GOLDBERG N J
出版信息
Br J Pharmacol Chemother. 1962 Oct;19(2):313-20. doi: 10.1111/j.1476-5381.1962.tb01194.x.
Abstract
The absorption of folic acid from segments of the small intestine of the rat has been measured in situ with tritium-labelled folic acid. The fraction absorbed was independent of concentration below 10(-6) M but was depressed to half at 4x10(-5) M. Direct measurements of fluxes showed that the mucosal --> serosal flux was about 14 times the serosal --> mucosal flux, and therefore that uptake of folic acid is an active process. In the ileum but not in the duodeno-jejunum, absorption was depressed by the presence of electrolyte. There was little difference in absorptive capacity between jejunum and ileum nor was there any significant change in animals suffering from a dietary deficiency of folic acid.
摘要
利用氚标记的叶酸对大鼠小肠各段叶酸的吸收进行了原位测定。吸收分数在浓度低于10⁻⁶ M时与浓度无关，但在4×10⁻⁵ M时降至一半。通量的直接测量表明，黏膜→浆膜通量约为浆膜→黏膜通量的14倍，因此叶酸的摄取是一个主动过程。在回肠而非十二指肠-空肠中，电解质的存在会抑制吸收。空肠和回肠的吸收能力几乎没有差异，叶酸饮食缺乏的动物也没有任何显著变化。
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