Kuwabara Y
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1992 Aug;44(8):982-6.
It goes without saying that the ideal situation for the immature fetus is growth within the normal environment of the maternal organism. Thus, in order to perform incubation that more closely resembles that of the fetus in utero, both in the extracorporeal and intracorporeal environment, an extrauterine fetal incubator, consisting of an artificial womb containing artificial amniotic fluid and a complete artificial placental system with a membrane oxygenator, was developed. Although similar experiments were performed in fetal lambs by Callaghan et al., Alexander et al., and Zapol et al., the fetuses only survived incubation for short periods of time, no longer than 55 hours. Previously, we reported the relatively long-term extrauterine incubation of goat fetuses, where by the longest period of incubation was 236 hours. However, several major problems, remained to be resolved. Here we present the case in which we succeeded in incubating a goat fetus for 3 weeks, followed by a trial birth from an artificial womb.
不言而喻，未成熟胎儿的理想生长环境是在母体的正常环境中。因此，为了在体外和体内环境中进行更类似于子宫内胎儿的孵化，开发了一种宫外胎儿孵化器，它由一个装有人工羊水的人造子宫和一个带有膜式氧合器的完整人工胎盘系统组成。尽管卡拉汉等人、亚历山大等人和扎波尔等人在胎羊身上进行了类似实验，但胎儿在孵化后仅存活了很短时间，不超过55小时。此前，我们报道了山羊胎儿相对长期的宫外孵化，其中最长孵化期为236小时。然而，仍有几个主要问题有待解决。在此，我们展示了成功将一只山羊胎儿孵化3周，随后从人造子宫中试产的案例。
