DAUTERMAN W C, MATSUMURA F
Science. 1962 Nov 9;138(3541):694-5. doi: 10.1126/science.138.3541.694.
The effects of minor variations in the malathion molecule upon the resistance of Culex tarsalis have been examined. By replacing the carboethoxy group by carbomethoxy, the 60-fold resistance to malathion is abolished. The results confirm the importance of carboxyesterase action in determining susceptibility to malathion.