DIXON J M, PAULLEY J W
Gut. 1963 Jun;4(2):169-73. doi: 10.1136/gut.4.2.169.
Rats were injected intraperitoneally with mecamylamine (Inversine) in doses that were believed to have reduced peristaltic activity in the small intestine. Large numbers of Escherichia coli were present throughout the lumen of the small intestine of animals treated for two or three days and killed within three hours of the last dose of the drug. Histological changes in the small intestinal mucosa of these animals included an increase in the number of goblet cells and shortening and thickening of the villi. Bacteria invaded the intestinal wall of some of the animals. Animals killed 24 hours after the last dose of the drug showed no significant change from the normal controls. The findings support the hypothesis that bacteria are removed mechanically from the normal small intestine by peristalsis. Certain of the histological changes are similar to those seen in the small intestine in malabsorptive conditions in man and the relationship between hypomotility, the bacterial population, and malabsorption is discussed.
给大鼠腹腔注射美加明（安血定），剂量据信可降低小肠的蠕动活性。在接受两到三天治疗且在最后一剂药物注射后三小时内处死的动物的小肠肠腔内，存在大量大肠杆菌。这些动物小肠黏膜的组织学变化包括杯状细胞数量增加以及绒毛缩短和变厚。一些动物的细菌侵入了肠壁。在最后一剂药物注射24小时后处死的动物与正常对照组相比无显著变化。这些发现支持了这样一种假说，即细菌通过蠕动从正常小肠中被机械性清除。某些组织学变化与人吸收不良状态下小肠所见的变化相似，并且还讨论了运动减弱、细菌数量与吸收不良之间的关系。
