大脑皮质淀粉样蛋白前体mRNA表达在阿尔茨海默病和其他神经退行性疾病中相似。

Cerebral cortical amyloid protein precursor mRNA expression is similar in Alzheimer's disease and other neurodegenerative diseases.

作者信息

Ohyagi Y, Takahashi K, Satoh Y, Makifuchi T, Tabira T

机构信息

Division of Demyelinating Disease and Aging, National Center of Neurology and Psychiatry, Tokyo, Japan.

出版信息

J Neurol Sci. 1992 Aug;111(1):33-8. doi: 10.1016/0022-510x(92)90109-x.

DOI:10.1016/0022-510x(92)90109-x

PMID:1402996

Abstract

The expression of 3 beta-amyloid protein precursor (APP) mRNAs (695, 751, and 770) in the cerebral cortex in Alzheimer's disease and other neurodegenerative diseases was analyzed by the S1 nuclease protection assay. We found no significant Alzheimer's disease-specific alteration of APP mRNA expression when compared to the other neurological diseases as controls. Since the expression of this mRNA was not correlated with amyloid deposition, it is possible that gliosis/neuronal loss may secondarily alter APP mRNA expression. However, the current study revealed no significant correlation between them.

摘要

采用S1核酸酶保护分析法，分析了阿尔茨海默病及其他神经退行性疾病患者大脑皮质中3种β淀粉样蛋白前体（APP）信使核糖核酸（mRNA，分别为695、751和770）的表达情况。与作为对照的其他神经疾病相比，我们未发现APP mRNA表达存在阿尔茨海默病特异性的显著改变。由于该mRNA的表达与淀粉样蛋白沉积无关，故胶质细胞增生/神经元丢失可能会继发改变APP mRNA的表达。然而，目前的研究未发现二者之间存在显著相关性。