Tanaka H
Department of Otolaryngology, Showa University, Fujigaoka Hospital, Yokohama.
Nihon Jibiinkoka Gakkai Kaiho. 1992 Aug;95(8):1239-46.
The nuclear DNA contents of 50 thyroid tumors were measured paraffin block samples and needle biopsies by using microscopic photometry, and the diagnostic value of this measurement was examined. Thyroid tumors included 17 papillary carcinomas, 15 follicular carcinomas and 18 benign tumors. The results confirmed the possibility of discriminating between benign and malignant tumors except in cases of follicular carcinoma with minimal invasion. This method seemed to be most valuable in the diagnosis of cases with class III FNA. A review was made of the relation between DNA content and prognostic factors, for example the degree of invasiveness of the thyroid tumor, intra-tracheal invasion, intra-thyroid metastasis and lymphatic metastasis. DNA content was increased only in cases with intra-tracheal invasion.
采用显微光度测定法对50例甲状腺肿瘤石蜡块样本及针吸活检样本的核DNA含量进行了测定，并对该测量的诊断价值进行了研究。甲状腺肿瘤包括17例乳头状癌、15例滤泡状癌和18例良性肿瘤。结果证实，除微小浸润性滤泡状癌外，鉴别良恶性肿瘤是有可能的。该方法在III级细针穿刺抽吸活检（FNA）病例的诊断中似乎最有价值。回顾了DNA含量与预后因素之间的关系，例如甲状腺肿瘤的浸润程度、气管内浸润、甲状腺内转移和淋巴转移。仅在气管内浸润的病例中DNA含量增加。
