Bhopale V M, Smith G, Jordan H E, Schad G A
School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.
J Parasitol. 1992 Oct;78(5):861-8.
Most recent authors suggest that larvae of the threadworm, Strongyloides ratti, migrate from a cutaneous infection site to the small intestine via the naso-frontal region of the head. However, the proportion of larvae that successfully reach the intestine having followed this pathway had not been determined. Using compartmental analysis we have obtained a comprehensive quantitative description of larval migration during a primary infection of rats with S. ratti. Mean residence times in organs through which larvae migrate were calculated and the proportion of the larvae arriving in the small intestine via the head was estimated as 0.5-0.86, depending on the mathematical model used to generate the estimate. With 50% or more of successful larvae using this pathway it is now reasonable to recognize the "head route" as an important migratory pathway for larvae traveling to their intestinal predilection site. During the first 12 hr in the host, larvae were difficult to recover from the skin and subjacent muscles of the infection site. Apparently, upon invading a host, many larvae enter a quiescent phase during which Baermannization, an active recovery technique, fails to recover them. Infections were short-lived, with the daily finite mortality rate for adult worms attaining 50-80% on day 16 of infection.
大多数近期的作者认为，鼠类圆线虫的幼虫从皮肤感染部位经头部的鼻额区域迁移至小肠。然而，沿此途径成功抵达肠道的幼虫比例尚未确定。我们通过房室分析，对大鼠初次感染鼠类圆线虫期间的幼虫迁移进行了全面的定量描述。计算了幼虫迁移所经器官的平均停留时间，并根据用于生成估计值的数学模型，估计经头部抵达小肠的幼虫比例为0.5 - 0.86。鉴于50%或更多的成功幼虫采用此途径，现在有理由将“头部途径”视为幼虫前往其肠道偏好部位的重要迁移途径。在宿主内的最初12小时内，很难从感染部位的皮肤及下方肌肉中回收幼虫。显然，侵入宿主后，许多幼虫进入静止期，在此期间，一种主动回收技术——贝尔曼氏法无法回收它们。感染是短暂的，感染第16天时成虫的每日有限死亡率达到50 - 80%。
