Fjaertoft M, Johannessen A C, Heyeraas K J
Dep. of Physiology, University of Bergen, Norway.
J Periodontal Res. 1992 Sep;27(5):534-8. doi: 10.1111/j.1600-0765.1992.tb01828.x.
Interstitial fluid pressure (IFP) in normal and inflamed gingiva of rats was measured by sharpened glass capillaries (diameter 2-4 microns) connected to a servocontrolled counterpressure system ad modum Wiederhielm. Gingival inflammation was induced by a steel ligature placed unilaterally around the first maxillary molar. After 8 weeks, the ligature was removed and measurements of IFP in normal and experimentally inflamed gingiva were made by puncture through the intact oral epithelium. Average IFP on the control side was 3.5 mm Hg in free, and 7.4 mm Hg in attached gingiva. Compared to the control side, IFP on the experimental inflamed side was elevated significantly (p less than 0.05) both in free and attached gingiva. In the ligated inflamed side IFP in free gingiva averaged 6.7 mm Hg, whereas in attached gingiva it showed a mean value of 10.4 mm Hg. Histological examinations showed a dense infiltrate of inflammatory cells in the connective tissue, while the contralateral control side showed normal features of epithelial and connective tissue. The present finding of increased IFP in the inflamed gingiva may in theory contribute to augmented crevicular fluid flow during inflammation.
通过连接到伺服控制反压系统的尖锐玻璃毛细管（直径2 - 4微米），按照Wiederhielm的方法测量大鼠正常和炎症牙龈中的组织液压力（IFP）。通过在上颌第一磨牙单侧放置钢丝结扎诱导牙龈炎症。8周后，移除结扎线，并通过完整的口腔上皮穿刺测量正常和实验性炎症牙龈中的IFP。对照侧游离龈的平均IFP为3.5毫米汞柱，附着龈为7.4毫米汞柱。与对照侧相比，实验性炎症侧游离龈和附着龈的IFP均显著升高（p < 0.05）。在结扎的炎症侧，游离龈的IFP平均为6.7毫米汞柱，而附着龈的平均值为10.4毫米汞柱。组织学检查显示结缔组织中有密集的炎性细胞浸润，而对侧对照侧显示上皮和结缔组织的正常特征。目前在炎症牙龈中IFP升高的发现理论上可能有助于炎症期间龈沟液流量的增加。
