溴苄铵和胍乙啶对[3H]-去甲肾上腺素摄取和释放的作用。
Actions of bretylium and guanethidine on the uptake and release of [3H]-noradrenaline.
作者信息
HERTTING G, AXELROD J, PATRICK R W
出版信息
Br J Pharmacol Chemother. 1962 Feb;18(1):161-6. doi: 10.1111/j.1476-5381.1962.tb01159.x.
Abstract
The effect of bretylium and guanethidine has been studied on the uptake and the spontaneous and reserpine-induced release of [(3)H]-noradrenaline in the rat heart and in the splenic nerve endings of the cat. Bretylium and guanethidine inhibited the uptake by the heart of circulating [(3)H]-noradrenaline. Bretylium blocked spontaneous and reserpine-induced release of [(3)H]-noradrenaline, while guanethidine caused release and partially antagonized the reserpine-induced release. Both compounds produced a transient liberation of [(3)H]-noradrenaline from splenic nerves, but blocked the release of the [(3)H]-catechol amine following stimulation of the splenic nerve.
摘要
已研究了溴苄铵和胍乙啶对大鼠心脏及猫脾神经末梢摄取、自发释放和利血平诱导释放[（3）H]-去甲肾上腺素的影响。溴苄铵和胍乙啶抑制心脏对循环中[（3）H]-去甲肾上腺素的摄取。溴苄铵阻断[（3）H]-去甲肾上腺素的自发释放和利血平诱导的释放，而胍乙啶则引起释放并部分拮抗利血平诱导的释放。两种化合物均使脾神经中的[（3）H]-去甲肾上腺素短暂释放，但阻断了刺激脾神经后[（3）H]-儿茶酚胺的释放。
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本文引用的文献
1
Effect of drugs on the uptake and metabolism of H3-norepinephrine.药物对H3-去甲肾上腺素摄取和代谢的影响。
J Pharmacol Exp Ther. 1961 Nov;134:146-53.
2
Fate of tritiated noradrenaline at the sympathetic nerve-endings.交感神经末梢处氚标记去甲肾上腺素的命运
Nature. 1961 Oct 14;192:172-3. doi: 10.1038/192172a0.
3
2-Octahydro-1-azocinyl)-ethyl]-guanidine sulfate (CIBA 5864-SU), a new synthetic antithypertensive agents.2-八氢-1-氮杂环辛烷基）-乙基]-胍硫酸盐（CIBA 5864-SU），一种新型合成抗高血压药物。
Experientia. 1959 Jul 15;15:267. doi: 10.1007/BF02158076.
4
Norepinephrine depletion as a possible mechanism of action of guanethidine (SU 5864), a new hypotensive agent.去甲肾上腺素耗竭作为新型降压药胍乙啶（SU 5864）一种可能的作用机制。
Proc Soc Exp Biol Med. 1960 Apr;103:871-2. doi: 10.3181/00379727-103-25702.
5
Preliminary observations on the antihypertensive properties of guanethidine.
Curr Ther Res Clin Exp. 1960 Jan;2:17-21.
6
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7
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J Pharmacol Exp Ther. 1959 Dec;127:251-6.
8
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9
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10
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J Pharmacol Exp Ther. 1961 Feb;131:223-30.
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