Hník P, Soukup T, Arutyunyan R, Ujec E
Pflugers Arch. 1977 Mar 11;368(1-2):129-33. doi: 10.1007/BF01063465.
Hind-limb muscles of new-born rats were de-efferented by removing the lumbosacral spinal cord. Spinal ganglia remained intact, together with their peripheral axon. The presence of sensory terminals in limb spindles, induces the full ultrastructural differentiation of muscle spindles, as has been shown previously. In the present paper we have shown by integrating the sensory discharges in the whole nerve from chronically de-efferented muscles that even several months after birth, muscle proprioceptors (probably mostly spindles) still maintain their basic mechanoreceptor properties. Although the limbs were completely immobilized throughout the whole experimental period, spindles from these chronically de-efferented muscles still responded as slowly adapting receptors. The dynamic component was also present in the integrated neurogram response during stretching. It thus appears that basic functional properties of rat muscle proprioceptor persist even when these receptors differentiate and survive without motor innervation and any adequate functional stimuli, i.e. under conditions of permanent disuse.
通过切除腰骶部脊髓使新生大鼠的后肢肌肉去传入。脊髓神经节及其外周轴突保持完整。如先前所示，肢体肌梭中感觉末梢的存在可诱导肌梭进行完全的超微结构分化。在本文中，我们通过整合来自长期去传入肌肉的全神经感觉放电表明,即使在出生后几个月，肌肉本体感受器（可能主要是肌梭）仍保持其基本的机械感受器特性。尽管在整个实验期间肢体完全固定，但这些长期去传入肌肉的肌梭仍作为慢适应感受器做出反应。在拉伸过程中，整合的神经图反应中也存在动态成分。因此，即使这些感受器在没有运动神经支配和任何适当功能刺激的情况下分化并存活，即在长期废用的条件下，大鼠肌肉本体感受器的基本功能特性似乎仍然存在。
