蔗糖八硫酸钾和硫糖铝的二维及氘诱导的微分同位素位移核磁共振表征
Two-dimensional and deuterium-induced, differential-isotope-shift nuclear magnetic resonance characterization of potassium sucrose octasulfate and sucralfate.
作者信息
Silvey G L
机构信息
Marion Merrell Dow Inc., Kansas City, MO 64137.
出版信息
J Pharm Sci. 1992 May;81(5):471-4. doi: 10.1002/jps.2600810517.
Two-dimensional and deuterium-induced, differential-isotope-shift NMR measurements have made it possible to assign completely all of the 1H and 13C resonances of potassium sucrose octasulfate (K8SOS) and thereby prove complete sulfation of the sugar moiety during synthesis. In addition, a comparison of the 13C NMR chemical shifts obtained for K8SOS and sucralfate made it possible to demonstrate that the sugar moiety in sucralfate is sucrose octasulfate (SOS8-). Finally, deuterium-induced, differential-isotope-shift and 13C NMR techniques were shown to be useful tools for detecting and characterizing carbon-containing impurities and hydrolysis products in solutions containing SOS8-.
二维和氘诱导的差分同位素位移核磁共振测量使得完全归属蔗糖八硫酸钾（K8SOS）的所有1H和13C共振成为可能，从而证明了在合成过程中糖部分的完全硫酸化。此外，对K8SOS和硫糖铝获得的13C核磁共振化学位移进行比较，使得能够证明硫糖铝中的糖部分是蔗糖八硫酸盐（SOS8-）。最后，氘诱导的差分同位素位移和13C核磁共振技术被证明是检测和表征含有SOS8-的溶液中含碳杂质和水解产物的有用工具。
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