Alexander G J, Kopeloff L M
Psychopharmacol Commun. 1976;2(5-6):379-90.
Convulsive responsiveness of O'Grady mice, inbred for susceptibility to audiogenic seizures, was decreased following treatment with the serotonin precursor, 5-hydroxytryptophan, or serotonin depletor, p-chlorophenylalanine. Neither agent exerted any antagonistic or synergistic action on the effect of the other. Upon sequential administration, their effects were additive. There was no indication that the increase in brain serotonin due to administration of its direct precursor interfered with the protective effect of p-chlorophenylalanine against seizures. Neither was there evidence that p-chlorophenylalanine-induced interruption of biosynthesis which led to severe depletion of brain serotonin affected the protective action of 5-hydroxytryptophan.
对声源性癫痫敏感的近交系奥格雷迪小鼠，在用血清素前体5-羟色氨酸或血清素耗竭剂对氯苯丙氨酸治疗后，惊厥反应性降低。两种药物对彼此的作用均未表现出任何拮抗或协同作用。依次给药时，它们的作用是相加的。没有迹象表明，给予其直接前体导致的脑血清素增加会干扰对氯苯丙氨酸对癫痫的保护作用。也没有证据表明，对氯苯丙氨酸诱导的生物合成中断导致脑血清素严重耗竭会影响5-羟色氨酸的保护作用。
