Franklin M R
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112.
J Biochem Toxicol. 1992 Summer;7(2):81-5. doi: 10.1002/jbt.2570070205.
Administration of 4,4'dipyridyl to rats induces the activities of xenobiotic transferases (phase II drug metabolizing enzymes), UDP-glucuronosyl-transferase and glutathione-S-transferase, and also the concentration and activity of cytochrome P450 (a phase I drug metabolizing enzyme). 2,2'Dipyridyl, an isomer possessing iron chelation properties, only induces the phase II enzymes. Although the magnitude of the phase II induction by 2,2'dipyridyl increases with increasing dosages, the selective induction of only phase II activities remains inviolate. Co-administration of 2,2'dipyridyl does not prevent 4,4'dipyridyl from inducing cytochrome P450, suggesting that the iron chelation property is not the factor that precludes 2,2'dipyridyl from coordinately inducing cytochrome P450 with the transferases.
给大鼠施用4,4'-联吡啶可诱导外源性物质转移酶（II相药物代谢酶）、UDP-葡萄糖醛酸基转移酶和谷胱甘肽-S-转移酶的活性，同时也会诱导细胞色素P450（I相药物代谢酶）的浓度和活性。2,2'-联吡啶是一种具有铁螯合特性的异构体，仅诱导II相酶。尽管2,2'-联吡啶对II相酶的诱导程度随剂量增加而增加，但仅对II相活性的选择性诱导保持不变。联合施用2,2'-联吡啶并不能阻止4,4'-联吡啶诱导细胞色素P450，这表明铁螯合特性并不是阻止2,2'-联吡啶与转移酶协同诱导细胞色素P450的因素。
