放线菌素D对青蛙胚胎的影响：依赖DNA的RNA顺序合成的证据

ACTINOMYCIN D EFFECTS IN FROG EMBRYOS: EVIDENCE FOR SEQUENTIAL SYNTHESIS OF DNA-DEPENDENT RNA.

作者信息

FLICKINGER R A

出版信息

Science. 1963 Sep 13;141(3585):1063-4. doi: 10.1126/science.141.3585.1063.

DOI:10.1126/science.141.3585.1063

Abstract

Early gastrulae of Rana pipiens exposed to actinomycin D for 2 days were then cultured in saline. The resulting larvae were immotile; histological examination revealed impaired development of axial nerve and muscle tissues, but normal differentiation of sensory, pronephric, heart, and digestive tissues; this suggests sequential synthesis of the different tissue-specific molecules of DNA-dependent RNA.

摘要

将暴露于放线菌素D两天的豹蛙早期原肠胚置于盐水中培养。所产生的幼体不能活动；组织学检查显示轴神经和肌肉组织发育受损，但感觉、前肾、心脏和消化组织分化正常；这表明DNA依赖性RNA的不同组织特异性分子是顺序合成的。