Sherbet Gajanan V, Lakshmi M S
Department of Zoology, University of Poona, Poona 7, India.
Zoologisches Institut der Universität, Poppelsdorfer Schloß, 53 Bonn a.Rh.
Wilhelm Roux Arch Entwickl Mech Org. 1964 Jul;155(4):429-436. doi: 10.1007/BF00577651.
The effect of chloramphenicol (CP) on the development ofPlanorbis exustus has been studied. The antibiotic is found to inhibit cleavage at high concentrations. At low concentrations development is blocked at early gastrulation. There are indications that the effect cannot be reversed by mere transfer of the embryos into normal medium, if they have been treated for 48 hours. If transfer into normal medium is made 24 hours after commencement of treatment, development is resumed.Gastrulae developed normally even in the presence of CP. In low concentrations of CP a characteristic delay in development is observed between the trochophore and hippo stages.The significance of this developmental inhibition has been discussed in relation to synthetic processes occurring in the various phases of development.The antilytic property of CP is evident in these experiments.
已研究了氯霉素（CP）对扁卷螺发育的影响。发现该抗生素在高浓度时会抑制卵裂。在低浓度时，发育在原肠胚形成早期受阻。有迹象表明，如果胚胎已接受48小时处理，仅将其转移到正常培养基中，这种影响无法逆转。如果在处理开始后24小时转移到正常培养基中，发育会恢复。即使存在CP，原肠胚也能正常发育。在低浓度的CP中，观察到担轮幼虫期和斧足期之间发育存在特征性延迟。已结合发育各阶段发生的合成过程讨论了这种发育抑制的意义。在这些实验中，CP的抗裂解特性很明显。
