LEIBOWITZ S, BODIAN M
J Clin Pathol. 1963 Jul;16(4):342-50. doi: 10.1136/jcp.16.4.342.
A method for the assay of vesical ganglion cells is described and the number and distribution of the neurones in three normal bladders was studied. Vesical ganglion counts were done in cases of the megaureter-megacystis syndrome, megaureter, bladder neck obstruction, megacystis associated with absent abdominal muscles, Hirschsprung's disease, and lumbar myelomeningocoele. A normal complement of neurones was found in each case. No evidence was found that the megaureter-megacystis syndrome is due to an agenesis of the peripheral autonomic ganglia similar to that in Hirschsprung's disease. Vesical ganglia were normal in the two cases examined and no clinical association was found between the two conditions in a large series of cases. Moreover, a study of the cell counts suggests that at least some of the reports of such a lesion are based upon an inadequate appreciation of the number and distribution of neurones in the normal urinary tract.
本文描述了一种检测膀胱神经节细胞的方法，并研究了三个正常膀胱中神经元的数量和分布。对巨输尿管-巨膀胱综合征、巨输尿管、膀胱颈梗阻、伴有腹肌缺如的巨膀胱、先天性巨结肠和腰骶部脊髓脊膜膨出病例进行了膀胱神经节计数。在每个病例中均发现神经元数量正常。未发现证据表明巨输尿管-巨膀胱综合征是由于外周自主神经节发育不全所致，与先天性巨结肠类似。在所检查的两个病例中，膀胱神经节正常，在大量病例中未发现这两种情况之间存在临床关联。此外，细胞计数研究表明，至少一些关于这种病变的报告是基于对正常尿路中神经元数量和分布的认识不足。
