照射小鼠同种异体与异种皮肤移植的同种移植反应的分离
DISSOCIATION OF HOMOGRAFT RESPONSE TO ALLOGENEIC VERSUS XENOGENEIC SKIN GRAFTS IN IRRADIATED MICE.
作者信息
TYAN M L, COLE L J
出版信息
Science. 1963 Aug 30;141(3583):813-4. doi: 10.1126/science.141.3583.813.
PMID:14045136
Abstract
Lethally x-irradiated (C3H x DBA/2)F(1) mice were protected with syngeneic (isogenic) bone marrow and/ or prior treatment with urethan and skin grafted at various times after irradiation. The ability to reject a first-set xenogeneic (heterologous) skin graft with normal vigor returned within 92 days; the first-set response to allogeneic (homologous) grafts was still impaired 350 days after irradiation.
摘要
用致死剂量的X射线照射（C3H×DBA/2）F1小鼠，然后用同基因（同源）骨髓和/或事先用乌拉坦处理，并在照射后的不同时间进行皮肤移植。以正常活力排斥首次移植的异种（异源）皮肤移植物的能力在92天内恢复；对同种异体（同源）移植物的首次反应在照射后350天仍受到损害。
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