BILODEAU M, ROY J
Can Med Assoc J. 1963 Sep 14;89(11):537-41.
This paper describes the results obtained in 200 patients with bronchopulmonary suppurative diseases who received kanamycin aerosol therapy under intermittent positive pressure and in whom bacterial sensitivity study (antibiogram) was favourable. This method of treatment was well tolerated and was practically free of side effects. In most cases the improvement was rapid, was maintained and was often life-saving. The first series contained nine patients with pulmonary tuberculosis and a constant finding of sputum positive for Koch bacillus; four of these became negative after eight weeks of treatment. This suggested that kanamycin aerosol therapy had some effect on the Koch bacillus and that the study should be continued with a much larger group of patients with tuberculous suppurative pulmonary diseases to determine the efficacy of this antibiotic.
本文描述了200例支气管肺化脓性疾病患者接受间歇正压下卡那霉素雾化治疗的结果，这些患者的细菌敏感性研究（抗生素敏感性试验）结果良好。这种治疗方法耐受性良好，几乎没有副作用。在大多数情况下，病情改善迅速，得以维持，且常常挽救生命。第一组有9例肺结核患者，痰中持续检出结核杆菌；其中4例在治疗8周后转阴。这表明卡那霉素雾化治疗对结核杆菌有一定作用，应继续对更多患有结核性化脓性肺病的患者进行研究，以确定这种抗生素的疗效。
