Andersen L J, Berthelsen A, Hansen H S
Department of Oncology, County Hospital of Copenhagen, Denmark.
J Otolaryngol. 1992 Jun;21(3):180-5.
Twenty-six patients with mucosal malignant melanoma of the upper respiratory tract and of the oral cavity were seen at the oncologic departments of eastern Denmark from 1955 to 1989. There were 17 males and nine females with an average age of 65 years. Primary symptoms lasted from one to 24 months and depended on localization of tumor. Five patients had lymph node metastases at the time of diagnosis; one also had distant metastases. Ten patients had surgery as primary treatment, 10 had combined surgery and radiotherapy and six had radiotherapy. Complete remission after primary treatment was seen in 22 cases (85%) and lasted from three to 94 months. Seventeen patients had recurrence, six of these had recurrence twice or three times. The five-year crude survival was 35% and only one patient (4%) lived more than 10 years. Recurrence-free survival among the 22 patients with initially complete response was 14%.
1955年至1989年期间，丹麦东部肿瘤科室共接诊了26例上呼吸道和口腔黏膜恶性黑色素瘤患者。其中男性17例，女性9例，平均年龄65岁。主要症状持续1至24个月，取决于肿瘤的位置。5例患者在诊断时已有淋巴结转移；1例同时伴有远处转移。10例患者接受了手术作为主要治疗，10例接受了手术联合放疗，6例接受了放疗。22例（85%）患者在初次治疗后实现完全缓解，缓解持续时间为3至94个月。17例患者复发，其中6例复发两次或三次。五年粗生存率为35%，只有1例患者（4%）存活超过10年。22例最初完全缓解的患者中，无复发生存率为14%。
