Takikawa H, Yamanaka M
Department of Medicine, Teikyo University School of Medicine.
Nihon Rinsho. 1992 Jul;50(7):1475-9.
Several amino acid transport systems have been known in the liver: sodium-dependent systems A, ASC and N for neutral amino acids, a sodium-dependent system for glycine (system Gly), sodium independent systems L1 and L2 for neutral amino acids, and sodium dependent systems for anionic amino acids. Recent studies with isolated sinusoidal and canalicular membrane vesicles have revealed that sodium dependent transport of an anionic amino acid, glutamate, and glycine occurs at the canalicular membrane, not at the sinusoidal membrane. Furthermore, solubilization and reconstitution of systems A and N has been reported and a 100 kD protein responsible for system N transport has been identified in the rat liver.
依赖钠的中性氨基酸系统A、ASC和N，依赖钠的甘氨酸系统（系统Gly），不依赖钠的中性氨基酸系统L1和L2，以及依赖钠的阴离子氨基酸系统。最近对分离的肝血窦和胆小管膜囊泡的研究表明，阴离子氨基酸谷氨酸和甘氨酸的依赖钠转运发生在胆小管膜，而非肝血窦膜。此外，已有关于系统A和N的增溶和重组的报道，并且在大鼠肝脏中已鉴定出一种负责系统N转运的100 kD蛋白质。
