Tanaka H, Nakahara K, Sakai S, Goto K
Department of Respiratory Disease, Gifu Municipal Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Apr;30(4):653-7.
A 40-year-old woman who had been diagnosed as having aspirin-induced asthma was admitted with stridor. She had a history of surgery for sinusitis and nasal polyps, and severe asthmatic attack requiring mechanical ventilation after administration of puranoprofen (Niflan). On the second day of hospitalization, she used a ketoprofen adhesive agent (Miltax, 30 mg) for a stiff shoulder. Stridor developed five hours later, progressing to a severe asthmatic attack with loss of consciousness, requiring mechanical ventilation. The serum level of ketoprofen was very high (81.7 ng/ml); therefore, provocation challenge test was performed to confirm the possible relationship between the ketoprofen adhesive agent and asthmatic attack. After closed patching of the agent (15 mg) on her lower leg, stridor developed, and FEV1.0 and PFR decreased, in association with an increase of the serum level of ketoprofen to a maximum of 38.0 ng/ml. These results show that the topical application of a ketoprofen adhesive agent induced the asthmatic attack by transdermal absorption in this patient.
一名40岁被诊断为阿司匹林诱发哮喘的女性因喘鸣入院。她有鼻窦炎和鼻息肉手术史，服用普拉洛芬（尼氟灭酸）后曾发生严重哮喘发作并需要机械通气。住院第二天，她因肩部僵硬使用了酮洛芬贴剂（密他克，30毫克）。五小时后出现喘鸣，进展为严重哮喘发作并伴有意识丧失，需要机械通气。酮洛芬血清水平非常高（81.7纳克/毫升）；因此，进行激发试验以确认酮洛芬贴剂与哮喘发作之间可能的关系。在其小腿封闭贴敷该药物（15毫克）后，出现喘鸣，第一秒用力呼气量（FEV1.0）和呼气峰值流速（PFR）下降，同时酮洛芬血清水平升高至最高38.0纳克/毫升。这些结果表明，酮洛芬贴剂的局部应用通过经皮吸收诱发了该患者的哮喘发作。
